Nowadays we are living in quite uncertain world where the threat of terrorist attacks is constantly increasing. Moreover, the menace of local wars is present almost everywhere in the world. Therefore, it is of primary interest for authorities to increase and optimize all possible resources in order to counteract these threats. As very recent history has showed that even nowadays these threats are unavoidable which makes it quite important to measure and evaluate the outcomes of already accomplished terrorist acts or war activities on human health and moreover, the long lasting effect on future generations. This implies implementation of adequate countermeasures for minimizing and diminishing of all dangerous consequences of terrorist and military activities.
The research groups that take part in the execution of this research have great expertise in bioengineering, biotechnology and genotoxicity testing which is proven by the large number of scientific papers published by them on the topic (Celik et al., 2009; El Idrissi et al., 2013; Genc et al., 2014; Georgieva et al., 2015a; Georgieva et al., 2015b; Hong et al., 2012; Jansen and Ruskovska, 2015; Miloshev et al., 2002; Ruskovska et al., 2014; Staneva et al., 2016). All four co-directors will supervise, manage and control the whole research scientific work during this phase as well as will supervise the young researchers during their project participation. Two young researches from Prof. Miloshev’s lab, two from Prof. Shen’s department, four from the laboratory of Prof. Ruskovska and two from the department of Prof. Celík will be involved in this part of project development. Their involvement will mainly include research and training. All young researchers will be responsible for the application of the techniques for bioengineering of live cells in order to make them sense illicit compounds and genotoxins at high speed and in miniscule concentrations. Short exchange training activities are foreseen for any one of them in other’s laboratory in order to gain experience and become apt at different techniques and moreover, to be able to gain and exchange knowledge and expertise. The affiliated member the Atlantic Club in Bulgaria will take care of the whole logistics of this sub-project phase, conveying good communication and collaboration among all project teams by organizing, managing and monitoring all steps of work by regular get-together events, online communication and coordination. Two young participants from Dr. Passy’s team will also participate in all these activities by regular involvement in all work concerning these communicational and logistic activities.
Scientific news
Milestone 3
ORIGINAL ARTICLES
Krasteva, N., Keremidarska-Markova, M., Hristova-Panusheva, K., Andreeva, T., Speranza, G., Wang, D., Draganova-Filipova, M., Miloshev, G. and Georgieva, M. (2019). Aminated graphene oxide as a potential new therapy for colorectal cancer, Oxidative Medicine and Cellular Longevity (in press).
Miloshev, G., Staneva, D., Uzunova, K., Vasileva, B., M., Draganova-Filipova, Zagorchev, P. , Georgieva, M. (2019). Linker histones and chromatin remodelling complexes maintain genome stability and control cellular ageing, Mechanismsm of Ageing and Development (177): 55-65: S0047-6374(18)30051-4. doi: 10.1016/j.mad.2018.07.002
https://www.sciencedirect.com/science/article/pii/S0047637418300514?via%3Dihub
Basu, P.; Saha, N.; Alexandrova, R.; Andonova-Lilova, B.; Georgieva, M.; Miloshev, G.; Saha, P. (2018). Biocompatibility and Biological Efficiency of Inorganic Calcium Filled Bacterial Cellulose Based Hydrogel Scaffolds for Bone Bioengineering. Int. J. Mol. Sci., 19, 3980. https://doi.org/10.3390/ijms19123980
https://www.mdpi.com/1422-0067/19/12/3980
ATTENDED CONFERENCES
32ND LANGENARGENER SYMPOSIUM DES BODENSEEFORUMS, ROTKREUZHAUS BREGENZ – 7-8TH DECEMBER, 2018
Miloshev talk: ▪ Field Detector of Genotoxic Activity
20-TH JUBILEE INTERNATIONAL SCHOOL ON CONDENSED MATTER PHYSICS – 3RD – 7TH SEPT., 2018, VARNA
Poster: ▪Dose-dependent genotoxicity of ammonia-modified graphene oxide particles in lung cancer cells
SECOND YOUNG SCIENTISTS SEMINAR ON GENETICS WITH INTERNATIONAL PARTICIPATION – 3RD – 5TH OCTOBER, SOFIA, BULGARIA
Talk: ▪ H. rhodopensis extracts influence genome activity of cell aiding it to cope with damaging effects
Poster: ▪ Assessment of the damages caused by anthropogenic pollution in the genome of the Black sea mussel
BIOMATERIALS INTERNATIONAL 2018 – 22ND – 25TH JULY, 2018, TOKYO, JAPAN
Poster: ▪ An intelligent “ready-to-use” system for field-employable genotoxicity surveillance
Poster: ▪ Cytotoxicity and genotoxicity effect of ammonia-functionalized graphene oxide nanoparticles in a colon adenocarcinoma cell line
CELL SYMPOSIA: AGING AND METABOLISM 2018 – 23RD – 25TH SEPT., SITGES, BARCELONA, SPAIN
Poster: ▪ UVA/B stress differently influences cells during their ageing
Milestone 2
Original articles
Georgieva,,Staneva, D.and Miloshev, G. (2017). TeleGenetics – Bringing Telemedicine Closer to the New Era of Personalized Medicine, In Benchmarking Telemedicine: Improving Health Security in the Balkans, IOS press, Editor Stone, C.S., pp: 42-48; ISBN print 978-1-61499-811-2; ISBN online 978-1-61499-812-9; https://www.iospress.nl/book/benchmarking-telemedicine-improving-health-security-in-the-balkans/
Miloshev, G., Staneva, D. and Georgieva, M. (2017). Genetics and Epigenetics in Telemedicine, In Benchmarking Telemedicine: Improving Health Security in the Balkans, IOS press, Editor Stone, C.S., pp:37-41; ISBN print 978-1-61499-811-2; ISBN online 978-1-61499-812-9; http://ebooks.iospress.nl/volumearticle/47765
Attended conferences
IUBMB FOCUSED MEETING ON “MOLECULAR ASPECTS OF AGEING AND LONGEVITY” – 16 – 19TH OCTOBER, ATHENS, GREECE
Poster: ▪ Epigenetic role of higher-order chromatin organization in cellular aging
WORLD BIODISCOVERY CONGRESS: 17 – 19TH JULY 2017, SOFIA, ▪ Comet assay – a sensitive tool for genotoxicity assessment of environmental stress in Mytilus galloprovincialis from the Bulgarian Black Sea coast