The Institute of Molecular Biology „Acad. Roumen Tsanev”

The Institute of Molecular Biology „Acad. Roumen Tsanev” at Bulgarian Academy of Sciences (IMB-BAS) is the leading national research institution in the area of Molecular and Cellular biology and Biochemistry. IMB is a member of UNESCO Global Network for Molecular and Cell Biology since 1995. Institutional web page: http://www.bio21.bas.bg/imb/. IMB is a team of research groups studying multiple aspects of molecular and cellular biology, molecular genetics and bioorganic chemistry. The mission of scientists is to conduct high-level fundamental and applied studies and their practical application in medicine, pharmacy and other areas of public well-being. IMB develops complex projects with national and international scientific organizations and companies; runs joint research projects in collaboration with many research groups in Europe, Canada, USA, Japan etc. IMB was a beneficent of two European Union granted project, i.e. under Operational Programme “Development of the Competitiveness of the Bulgarian Economy” 2007-2013 BG161PO003-1.2.04-0013-C0001, co-financed by the European Union through the European Regional Development Fund and the State Budget of the Republic of Bulgaria and under Operational programme Human resources at the EU 7th Framework programme “The young scientists – a potential for development of science and technologies in the field of Molecular Biology” BG051РО 001- 3.3.04/58. IMB comprises four departments: Gene Regulation, Molecular biology of cell cycle, Structure and function of chromatin, Biochemical pharmacology and drug design, and 2 specialized laboratories: Laboratory of yeast molecular genetics and Medical and biological research laboratory. IMB scientists produces 20-30 high quality scientific papers per year published in peer reviewed journals. In the last evaluation by the European Science Foundation the Institute was rated AAA (quality / performance, socio-economic impact and prospects). Besides research, IMB ambition is to achieve excellence in teaching and education. IMB is licensed to carry out education of Ph.D. students in three disciplines: Molecular Biology, Molecular Genetics and Bioorganic Chemistry. IMB carries out training and education in molecular biology and its related disciplines on bachelor’s, master’s and Ph.D. programs. The scientists use shared research facilities: equipment for two-dimensional separation of fluid-fluid proteome analysis (PF2D Eprogen), High robotic system for cellular and biochemical analysis (Biomek 3000 and DTX880, Beckman Coulter), Gel documentation systems, a system for infrared imaging visualization (LI-COR Biosciences Odyssey), Real-time PCR machine (Rotor-Gene 6000, Qiagen), Flow cytometer (Becton Dickinson FACSCalibur) and three fully equipped laboratories for cell and tissue culturing, including incubators, laminar flow boxes, reverse phase-contrast microscope, storage containers for liquid nitrogen. In addition, the researchers make free use of departments’ own equipment. IMB is building a centre for modern microscopy, which includes so far a spinning disc Andor Revolution confocal microscope with a laser micro irradiation, an epifluorescence microscope Zeiss Axiovert 200M equipped with lenses with high resolution, ApoTome system, AxioCam MR3 CCD camera Andor Ixon EMCCD camera. The last signed project under the Operational Programme “Development of the Competitiveness of the Bulgarian Economy” 2007-2013 enabled the purchase of a nano-Liquid Chromatography-Mass Spectometry (nLC-MS) LTQ Orbitrap (Thermo Scientific), a New Generation Sequencer (NGS) MiSeq (Illumina), nanocalorimeter ITC DSC and peptide synthesizer. IMB personnel have full access to all facilities including library, conference hall, apparatus rooms and so on. In addition, IMB provides its researchers with administrative, legislative and accountancy support, files scientific reports and research products in accordance with Bulgarian regulations and bears administrative and penal liability in case of breach of low. The Laboratory of Yeast Molecular Genetics (LYMG) is part of the Institute of Molecular Biology “Roumen Tsanev”, Bulgarian Academy of Sciences. LYMG web site: http://www.chromatinepigenetics.com/. Assoc. Prof. George Miloshev, PhD, is head of the laboratory. Two post-docs, one PhD student, two MSc students and two BSc students are working on several projects aiming to understand the intricate molecular mechanisms that control gene expression in eukaryotes in norm and pathology. The team has more than 100 scientific publications in international peer-review scientific journals and has participated in a number of international and national projects, conferences and workshops. Laboratory of Yeast Molecular Genetics was a beneficent of European Union granted project under Youth in Action Programme 2013, Grant BG13/A1.2/242/R2. A big part of the lab activities involves dissemination of scientific achievements among general public, education and training of young people with interest in the field of Molecular Biology and Genetics, Epigenetics and Biochemistry. Laboratory participation in collaborative scientific projects as well as projects aiming at disseminating science among students and pupils guarantees high level expertise of the team in all fields of Biological science. The lab personnel is also good at teaching as regular lecture and practical courses are being held and organized by it and involve students from Sofia University “St. Kliment Ohridski”, Sofia Medical niversity, Plovdiv Medical University and others. Moreover, high school lectures are also held of the lab personnel and target interested in science young people in their last years at school. As far as the NATO SPS-MYP project is concerned the laboratory stuff that will be involved in the project includes the laboratory Head Prof. Miloshev, the two post-docs, Dr. Staneva, PhD and Dr. Georgieva, PhD and the PhD student Borislava Kukurina, four students (MSc and BSc). The four experienced scientists will be fully responsible for the project implementation, young scientists’ teaching and training and the collaboration among all partners. All the above mentioned facilities and activities give the laboratory staff the desired qualifications for the successful management and implementation of the NATO SPS-MYP project proposal.